Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis

Revista Brasileira de Farmacognosia

Miranda, George E.C.¹  Santos, Barbara V.O.¹  Souto, Janeusa T.¹  Universidade Federal do Rio Grande do Norte, Natal, Brasil¹  Abílio, Gisely M.F.¹  Silveira, Ericka J.D.¹  Bitencourt, Mariana A.O.¹  Araújo-Júnior, João X. de¹  Laboratorio de Química Medicinal, Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Alagoas, Maceió, Brasil¹  Silva, Hylarina M.D.¹  Fundação Oswaldo Cruz, Recife, Brasil¹  Moura, Adolpho M.A.¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹ 

关键词:  Caulerpa mexicana;    Green algae;    Inflammation;    Ulcerative colitis;    Cytokines;    Tissue damage;   

DOI  :  10.1016/j.bjp.2015.10.001

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, are characterized by chronic and relapsed gut inflammation. Caulerpa mexicana is a type of green marine algae that can be found in tropical areas, such as the Brazilian Coastland. These macrophytes exhibit in vitro and in vivo anti-inflammatory properties such as the ability to reduce both cell migration to different sites and edema formation induced by chemical irritants. The aim of this study was to examine the effect of the C. mexicana methanolic extract on the treatment of colitis induced by dextran sodium sulfate. Acute experimental colitis was induced in BALB/c mice by treatment with 3% dextran sodium sulfate orally for 14 days. During this 14-day period, C. mexicana methanolic extract (2 mg/kg/day) was given intravenously on alternate days. Treatment with the methanolic extract significantly attenuated body weight loss and severe clinical symptoms. This was associated with a remarkable amelioration of colonic architecture disruption and a significant reduction in pro-inflammatory cytokine production. These results suggest that the anti-inflammatory action of C. mexicana methanolic extract on colorectal sites may be a useful therapeutic approach for inflammatory bowel diseases.

【 授权许可】

Unknown