Is phototridachiahydropyrone a true natural product?

Revista Brasileira de Farmacognosia

Istituto di Chimica Biomolecolare, Pozzuoli, Italy¹  Cimino, Guido¹  Gavagnin, Margherita¹  Mollo, Ernesto¹ 

关键词:  Marine natural products;    Polypropionates;    Sacoglossans;    Tridachiahydropyrones;   

DOI  :  10.1016/j.bjp.2015.07.028

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The occurrence of (−)-phototridachiahydropyrone (5) in nature has been proven. This compound has been now identified as minor component of the extract of marine sacoglossan mollusk Elysia crispata from which the main (−)-tridachiahydropyrone (4) was previously described. Synthetic (±)-5 was formerly obtained by Moses’ group by biomimetic photochemical conversion of (±)-tridachiahydropyrone (4). The same authors suggested that compound 5 had to be a natural product derived from precursor 4 “yet to be discovered”. Comparison of CD profiles of natural (−)-4 and (−)-5 indicated the same absolute configuration for both compounds. This evidence is in agreement with the concerted mechanism proposed for the photochemical conversion.

【 授权许可】

Unknown