Preformulation study and influence of DMSO and propylene glycol on the antioxidant action of isocoumarin paepalantine isolated from Paepalanthus bromelioides

Revista Brasileira de Farmacognosia

Damasceno, João Paulo Loureiro¹  Gonçalves, Rita de Cássia Ribeiro¹  Giuberti, Cristiane dos Santos¹  Universidade Federal do Espírito Santo, Vitória, Brazil¹  Kitagawa, Rodrigo Rezende¹ 

关键词:  Antioxidant;    Paepalantine;    Preformulation;   

DOI  :  10.1016/j.bjp.2015.07.008

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Coumarins are phenolic compounds and have various biological properties, including antioxidant activity. The isocoumarin paepalantine, isolated from of Paepalanthus bromelioides Silveira, Eriocaulaceae, exhibits a wide range of biological activities, including antimicrobial, anti-inflammatory, antioxidant and cytotoxic properties. Studies on paepalantine often use dimethylsulfoxide as a solvent. However the dimethylsulfoxide interferes with antimicrobial, cytotoxic and antioxidant assays. Thus, this study aims to evaluate alternative solvents for paepalantine and evaluate their potential to interfere with antioxidant assays (ABTS•+, O2•-, HOCl). Of the selected solvents, propylene glycol had good solubility and remained stable throughout the study period. The results suggested that there is no interference from propylene glycol in antioxidant assays, while dimethylsulfoxide significantly interfered with the HOCl assay. The antioxidant assays showed that paepalantine demonstrated similar or even better antioxidant activity than Trolox. Thus, propylene glycol may be the solvent of choice for paepalantine, a compound that has significant biological potential.

【 授权许可】

Unknown