Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Revista Brasileira de Farmacognosia

Mocelin, Ricieri¹  Sachett, Adrieli¹  Piccinin, Giana¹  Zanatta, Leila¹  Schönell, Amanda P.¹  Santo, Glaucia D.¹  Wildner, Silvana M.¹  Roman Junior, Walter A.¹  Universidade Comunitária da Região de Chapecó, Chapecó, BR¹  Bevilaqua, Fernanda¹  Giachini, Marta¹  Chitolina, Rafael¹  Fantin, Emily¹  Ibagy, Eduarda¹  Schneider, Mariane¹ 

关键词:  Antihyperlipidemic activity;    Arnica-do-brasil;    Asteraceae;    Hypoglycemic;   

DOI  :  10.1016/j.bjp.2015.05.001

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Solidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g) in control group (C), hydroalcoholic extract (125, 250 or 500 mg/kg p.o.; n = 6) or glibenclamide (10 mg/kg p.o.; n = 6). After 30 min, glucose (4 g/kg) was administered. Rats treated with hydroalcoholic extract 500 demonstrated decreased glucose levels at 180 min (-22.1%), when compared with group C, similar to glibenclamide. Moreover, treatment with hydroalcoholic extract 500 significantly increased the glycogen content in the liver and soleus muscle, and hydroalcoholic extract 250 specifically inhibited the enzyme maltase when compared with group C. Furthermore, all hyperglycemic rats treated with hydroalcoholic extract (125, 250 and 500) exhibited an accentuated decrease in total cholesterol levels (-36.8%, -36.7% and -41.3%, respectively). Our results suggest that hypoglycemic and hypolipidemic effects of hydroalcoholic extract could be associated with increased production and release of insulin as well as with insulinotropic and antioxidant effects.

【 授权许可】

Unknown