Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

Revista Brasileira de Farmacognosia

Nanayakkara, Dhammika¹  Bastos, Jairo Kenupp¹  Sousa, João Paulo Barreto de¹  Universidade do Vale do Itajaí, Itajaí, BR¹  Santin, José Roberto¹  University of New England, Portland, US¹  Lemos, Marivane¹  Mizuno, Cassia Suemi¹  Universidade de São Paulo, Ribeirão Preto, BR¹  Andrade, Sérgio Faloni de¹  University of Mississippi, US¹  Boeing, Thaise¹ 

关键词:  Gastric ulcer;    Gastroprotection;    Flavonoids;    Terpenes;   

DOI  :  10.1016/j.bjp.2015.05.005

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Gastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in the treatment produce several adverse effects. In this context, the search for new therapeutic antiulcer agents is essential, and medicinal plants have great potential. Here, we investigated the gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves and its isolated compounds. The phytochemistry studies and the compounds isolations were performed using chromatographic and spectroscopic methodologies. The hydroalcoholic extract was evaluated using ethanol/HCl, non-steroidal anti-inflammatory drug, stress-induced-ulcer and chronic ulcer-model. The effects on gastric content volume, pH, total acidity and mucus stomach production were evaluated in the pylorus ligated-model. The C. langsdorffii extract obtained from leaves (50, 250 or 500 mg/kg) reduced the injured area compared to control group in all experiments. The extract showed a significant decrease in the total gastric juice acidity and an increase in mucus production (500 mg/kg) when compared to vehicle. Among isolated compounds (30 mg/kg) α-humulene, β-caryophyllene and caryophyllene oxide showed greater gastroprotective activity in the ethanol/HCl induced ulcer model. The data herein obtained shown that C. langsdorffii leaves extract and isolated compounds from it, presented gastroprotective properties in different animal models of gastric ulcer. These effects may be associated with the ability of the extract to decrease gastric secretion and increase the mucus production.

【 授权许可】

Unknown