Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots

Revista Brasileira de Farmacognosia

Universidade Estadual de Mato Grosso do Sul, Brazil¹  Tófoli, Danilo¹  Universidade Federal de Mato Grosso do Sul¹  Ruiz, Ana L. T. G.¹  Rodrigues, Fátima A.¹  Fernandes, Elaine de S.¹  Universidade Estadual de Campinas, Brazil¹  Foglio, Mary A.¹  Silva, Rogério C. L.¹  Imamura, Paulo M.¹  Minguzzi, Sandro¹  Universidade Federal de Mato Grosso do Sul, Brazil¹  Carvalho, João E. de¹ 

关键词: cytotoxic activity;    diterpene;    Euphorbiaceae;    Jatropha ribifolia;    sesquiterpene;   

DOI  :  

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and characterized by spectroscopic techniques (NMR of 1H, 13C and IR). The in vitro antiproliferative activity of jatrophone showed selectivity in a concentration dependent way with Total Inhibition growth of: glioma 0.57 µg mL-1 (U251), breast cancer 9.2 µg mL-1 (MCF-7), adriamycin-resistant ovarian cancer 0.96 µg mL-1 (NCI-ADR/RES), kidney 4.2 µg mL-1 (786-0), prostate cancer 8.4 µg mL-1 (PC-3), colon cancer 16.1 µg mL-1 (HT29) and leukemia 0.21 µg mL-1 (K-562).

【 授权许可】

Unknown