期刊论文详细信息
Revista Brasileira de Farmacognosia
Chemical constituents and evaluation of cytotoxic and antifungal activity of Lantana camara essential oils
Lopes, José A. D.1  Silva, Davi da1  Sousa Júnior, Gustavo R. de1  Costa, José G.M. da1  Novafapi, Brazil1  Rocha, Márcio dos S.1  Universidade Regional do Cariri, Brazil1  Mobin, Mitra1  Lima, Sidney G. de1  Medeiros, Lídia B. P.1  Saffi, Jenifer1  Universidade Federal do Piauí, Brazil1  Universidade Federal Rio Grande, Brazil1  Citó, Antônia M. das G. L.1  Moura, Dinara J.1 
关键词: Lantana camara;    essential oil;    chemical composition;    antifungal;    citotoxic activity;   
DOI  :  
来源: Sociedade Brasileira de Farmacognosia
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【 摘 要 】

The essential oil (EO) of aerial parts of Lantana camara L., Verbenaceae, from Simões, Piaui, Northeast of Brazil, were obtained by hydrodistillation and analyzed by GC-FID and GC-MS techniques. In total, 68 compounds were identified. The most representative compounds of the oil were mono and sesquiterpenes. The main compounds found in the oil of the leaves in different months were β-caryophyllene (10.5%, in June of 2009), sabinene (7.98%, in September of 2008), limonene (7.68%, in September of 2008), spathulenol (11.64%, in September of 2008). The oil from stems of L. camara was characterized by a largest amount of sesquiterpenoids, with spatulenol (15.9%) and caryophyllene oxide (17.1% in June of 2009), as main components. β-Gurjunene (32.7%, in September of 2008) was the most prominent compound in the stems oils, which was absent or at very low relative abundance in leaves. L. camara essential oils from leaves were cytotoxic to V79 mammalian cells and also to Artemia salina, showing 50% lethal concentration (LC50) values from 0.23 µg/mL. The in vitro data obtained in this study suggested that EO may also be effective treating yeast infection in patients infected with fluconazole and terbinafine resistant isolates, but its toxicity must be monitored carefully.

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