Caulerpin as a potential antiviral drug against herpes simplex virus type 1

Revista Brasileira de Farmacognosia

Pinto, Ana Maria¹  Giongo, Viveca¹  Ribeiro, Michele S.¹  Cirne-Santos, Claudio¹  Macedo, Nathália Regina Porto Vieira¹  Teixeira, Valéria L.¹  Universidade Federal Fluminense, Brazil¹  Villaça, Roberto C.¹  Ferreira, Wilton¹  Paixão, Izabel C. N. P.¹ 

关键词: Caulerpa;    caulerpin;    Herpes simplex type 1;     cytotoxicity;     antiviral;   

DOI  :  10.1590/S0102-695X2012005000072

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

About 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae with potential antiviral activity represents a good opportunity for the development of antiviral drugs. Caulerpin, the major product from the marine algae Caulerpa Lamouroux (Caulerpales), is known for its biological activities such as antioxidant, antifungal, acetylcholinesterase inhibitor (AChE) and antibacterial activity. In this work, we show that caulerpin could be an alternative to acyclovir as an anti-HSV-1 drug that inhibits the alpha and beta phases of the replication cycle.

【 授权许可】

Unknown