Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

Revista Brasileira de Farmacognosia

Malvar, David C.¹  Florentino, Iziara F.¹  Guilhon, Giselle M. S. P.¹  Universidade Federal de Santa Catarina, Brazil¹  Ferreira, Raquel T.¹  Universidade Federal Rural do Rio de Janeiro, Brazil¹  Universidade Federal do Pará, Brazil¹  Lima, Thereza C. M. de¹  Rocha, Fabio F.¹  Universidade Federal de Goiás, Brazil¹  Costa, Elson A.¹  Vanderlinde, Frederico A.¹ 

关键词: Mikania lindleyana anti-inflammatory antinociceptive Asteraceae sucuriju phytomedicine;   

DOI  :  10.1590/S0102-695X2011005000190

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.

【 授权许可】

Unknown