In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Revista Brasileira de Farmacognosia

Ramos, Rafael C.¹  Silva Filho, Ademar A. da¹  Veneziani, Rodrigo C. S.¹  Rodrigues, Vanderlei¹  Magalhães, Lizandra G.¹  Aguiar, Gabriela P.¹  Cunha, Wilson R.¹  Universidade de Franca, Brazil¹  Melo, Nathalya I. de¹  Tonuci, Ligia R. S.¹  Dias, Herbert J.¹  Wakabayashi, Kamila A. L.¹  Universidade Federal de Juiz de Fora, Brazil¹  Groppo, Milton¹  Mantovani, André L. L.¹  Crotti, Antônio E. M.¹  Universidade de São Paulo, Brazil¹  Aguiar, Daniela P.¹ 

关键词: essential oil praziquantel Schistosoma mansoni schistosomicidal agents Tagetes erecta;   

DOI  :  10.1590/S0102-695X2011005000202

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 µg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites and the separation of coupled pairs into individual male and female at 100 µg/mL after 24 h. The viability of adult worm groups treated with the TE-EO at 100 µg/mL was similar to that of groups treated with praziquantel (positive control). In addition, the oil promoted the inhibition of eggs development at all the tested concentrations. These data indicate that the TE-EO could be considered as a promising source for the development of new schistosomicidal agents.

【 授权许可】

Unknown