Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin

Revista Brasileira de Farmacognosia

Carlos, Iracilda Zeppone¹  Raddi, Maria Stella Gonçalves¹  Universidade Federal do Espírito Santo, Brazil¹  Vilegas, Wagner¹  Universidade Estadual Paulista Júlio de Mesquita Filho, Brazil¹  Kitagawa, Rodrigo Rezende¹ 

关键词: 5-methoxy-3;    4-dehydroxanthomegnin;    cytotoxic activity;    immunomodulatory;    naphthoquinone;   

DOI  :  10.1590/S0102-695X2011005000136

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.

【 授权许可】

Unknown