Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum

Revista Brasileira de Farmacognosia

Kaplan, Maria Auxiliadora C.¹  Universidade Federal do Rio de Janeiro, Brazil¹  Marques, André Mesquita¹  Soares, Rosangela M. de A.¹  Barreto, Anna Léa Silva¹  Romanos, Maria Teresa Villela¹  Curvelo, José Alexandre da R.¹ 

关键词: essential oil Leishmania amazonensis nerolidol Piper claussenianum;   

DOI  :  10.1590/S0102-695X2011005000157

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Leishmaniasis is one of the most neglected tropical diseases, representing a group of parasitic diseases worldwide spread, occurring in 88 tropical and subtropical countries. Approximately 350 million people live in areas of active transmission of leishmaniasis, with about 1-2 million estimated new cases occurring every year. More than 90% of the cutaneous cases appear in developing countries. Efforts to improve the therapeutic arsenal against leishmaniasis have led to the search for new and cheap range of drugs. In this study, the nerolidol-rich essential oil from Piper claussenianum (Miq.) C. DC., Piperaceae, was assayed on arginase activity of Leishmania amazonensis. The effect of this essential oil on arginase activity levels showed an enzyme inhibition of 62.2%. This result stimulates the scientific interest about the potential value of this plant species on neglected diseases as potential new natural product source of pharmacological interest for the treatment of leishmaniasis.

【 授权许可】

Unknown