Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Revista Brasileira de Farmacognosia

Cáceres, Armando¹  Álvarez, Luis¹  Universidad Mayor de San Andrés, Bolivia¹  Morales, Julio¹  Salamanca, Efraín¹  Henriques, Amelia T.¹  Apel, Miriam A.¹  Vásquez, Yelkaira¹  Universidad Federal Rio Grande do Sul, Brasil¹  Giménez, Alberto¹  Gupta, Mahabir P.¹  Universidad de Panamá, Panamá¹  Cruz, Sully M.¹  Universidad de San Carlos, Guatemala¹ 

关键词: antimicrobial activity;    cytotoxic activity;    essential oil;    extracts;    Guatemala;    Piper;   

DOI  :  10.1590/S0102-695X2011005000110

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 µg/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 µg/mL), and epimastigotes of Trypanosoma cruzi (51.9 µg/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 µg/mL), and the dichloromethane extract against Leishmania (55.8-76.3 µg/mL) and T. cruzi (45.8 µg/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.

【 授权许可】

Unknown