Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, extract shows hypoglycemic effect and eases oxidative stress in alloxan-induced diabetic rats

Revista Brasileira de Farmacognosia

Alam, Mohammad A.¹  University of Dhaka, Dhaka, Bangladesh¹  Chowdhury, Sadia A.¹  University of Wolverhampton, West Midland, UK¹  Subhan, Nusrat¹  Nahar, Lutfun¹  Rashid, Mohammad A.¹  Sarker, Satyajit D.¹  Awal, Mohammad A.¹  Mostofa, Mahbub¹  Northern University, Dhaka, Bangladesh¹  Hasan, Choudhury M.¹  Stamford University, Dhaka, Bangladesh¹  Bangladesh Agricultural University, Mymensingh, Bangladesh¹ 

关键词: Anthocephalus cadamba;    Rubiaceae;    alloxan-induced oxidative stress;    diabetes;   

DOI  :  10.1590/S0102-695X2011005000033

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The hydroethanolic extract of the flowering tops of Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, a Bangladeshi medicinal plant, was studied for its potential hypoglycemic effect and antioxidant property in alloxan-induced diabetic rats. The extract induced significant reduction in serum glucose, and transaminases, e.g. aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatases (ALP), activities. Significant changes in the thiobarbituric acid reactive substances (TBARS), peroxidase and catalase levels during the experimental period were also observed. The results established that the hydroethanolic extract of the flowering tops of A. cadamba possesses hypoglycemic property and is able to protect liver and brain from oxidative damages caused by diabetes.

【 授权许可】

Unknown