Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Revista Brasileira de Farmacognosia

Korean Collection of Herbal Extracts, Republic of Korea¹  Kongju National University, Republic of Korea¹  Sancheti, Shruti¹  Kim, Hae-Ran¹  Seo, Sung-Yum¹  You, Young-Han¹  Sancheti, Sandesh¹  Bafna, Mayur¹ 

关键词: antihyperglycemic;    antihyperlipidemic;    antioxidant;    Boehmeria nivea root;    diabetes;    streptozotocin;   

DOI  :  10.1590/S0102-695X2011005000021

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The potential role of 80% methanolic extract of Boehmeria nivea (L.) Gaudich., Urticaceae, root in the treatment of diabetes, along with its antihyperlipidemic and antioxidant effects, was studied in streptozotocin-induced diabetic male Wistar rats. Preliminary screening of the extract revealed the presence of polyphenolics and flavonoids. The animal study was conducted with variable doses of 125, 250 and 500 mg/kg of extract for 21 days in diabetic rats. A significant effect was observed at a dose of 500 mg/kg, which was comparable to the standard drug, glibenclamide. Administration of the extract at a 500 mg/kg dose resulted in a significant reduction of fasting blood glucose, total cholesterol, triglycerides, blood urea, alanine aminotransferase, aspartate aminotransferase, urine sugar and urine ketone levels in diabetic rats in comparison with the diabetic control group. Additionally, this dose significantly increased body weight, hemoglobin, plasma total protein, high density lipoprotein cholesterol, liver glycogen content, superoxide dismutase, reduced glutathione and catalase levels in diabetic rats at the end of 21 days of treatment. Therefore, dietary supplementation with Boehmeria nivea root extract could be beneficial for correcting hyperglycemia, hyperlipidemia and enhancing the antioxidant defense system.

【 授权许可】

Unknown