Effects of seco-steroids purified from Physalis angulata L., Solanaceae, on the viability of Leishmania sp

Revista Brasileira de Farmacognosia

Hospital São Rafael, Salvador, Brazil¹  Ribeiro, Ivone M.¹  Soares, Milena B. P.¹  Santos, Luana A.¹  Guimarães, Elisalva T.¹  Tomassini, Therezinha B. C.¹  Santos, Ricardo Ribeiro dos¹  Lima, Milena S.¹  Santos, Washington L. C. dos¹  Fundação Oswaldo Cruz, Salvador, Brazil¹  Fundação Oswaldo Cruz, Rio de Janeiro, Brazil¹ 

关键词: Leishmania sp.;    physalins;    promastigotes;    seco-steroids.;   

DOI  :  10.1590/S0102-695X2010005000036

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Physalis angulata L., Solanaceae, is an annual herb commonly used in popular medicine in many tropical and subtropical countries. P. angulata extracts contain a variety of substances, but little is known about their pharmacological activities. In this work we investigated the in vitro antileishmanial activity of seco-steroids (physalins) purified from P. angulata. Addition of physalins B, F, and G caused a concentration-dependent inhibition in the growth of L. amazonensis promastigotes, being the IC50 values were 6.8, 1.4, and 9.2 μM, respectively. Physalin D was less active and had an IC50 value of 30.5 μM. Physalins were also active in cultures of other Leishmania species (L. major, L. braziliensis, and L. chagasi). Our results demonstrate the potent antileishmanial activity of physalins in cultures of Leishmania species of the New and Old Worlds and suggest the therapeutic potential of these seco-steroids in leishmaniasis.

【 授权许可】

Unknown