Therapeutic benefits of Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, in experimental models of pain and inflammation

Revista Brasileira de Farmacognosia

Oliveira, Valter O. B¹  Passos, Ailane M. P. R¹  Universidade Federal de Sergipe, São Cristóvão, Brazil¹  Lima, Clésio A¹  Mendes, Sandra S¹  Thomazzi, Sara M¹  Estevam, Charles S¹  Bomfim, Rangel R¹  Oliveira, Juliana P. R¹  Araujo-Neto, Vitor¹ 

关键词: anti-inflammatory;    antinociceptive;    Sideroxylon obtusifolium;    Sapotaceae.;   

DOI  :  10.1590/S0102-695X2010005000043

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, is a plant with analgesic and anti-inflammatory activities used in folk medicine. In order to evaluate the actions of this plant, studies were performed on antinociceptive and anti-inflammatory activities with the ethanol extract (EE) of inner bark (100-400 mg/kg). Oral treatment with the EE elicited inhibitory activity (200 and 400 mg/kg, p<0.01) on acetic acid effect and reduced (100, 200, and 400 mg/kg, p<0.001) the formalin effect at the second-phase, however it did not elicit any inhibitory effect on hot-plate test. Carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity were reduced with the EE at 100, 200, and 400 mg/kg (p<0.001). In conclusion, the EE of Sideroxylon obtusifolium shows antinociceptive and anti-inflammatory activities, supporting the folkloric usage of the plant to treat pain and various inflammatory diseases.

【 授权许可】

Unknown