Evaluation mutagenic and antimutagenic activity of Aloe vera in Allium cepa test and micronucleus test in human binucleated lymphocytes

Revista Brasileira de Farmacognosia

Restani, Rossana G.¹  Sturbelle, Régis T.¹  Universidade Federal de Pelotas, Pelotas, Brasil¹  Martino-Roth, Maria da Graça¹  Oliveira, Gisele R. de¹  Universidade Católica de Pelotas, Pelotas, Brasil¹  Pinho, Daiane S. de¹  Garcias, Gilberto de L.¹ 

关键词: Aloe vera;    Allium cepa;    Liliaceae;    mutagenicity;    antimutagenicity.;   

DOI  :  10.1590/S0102-695X2010000300019

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Some of the substances in plant may have mutagenic effects, while others may cancel or mitigate these effects. It is estimated that more than 200 active substances compose the gel of Aloe vera, and the polysaccharides increases in 30%, and many of the therapeutic benefits, nutrition and cosmetics are allocated to them. The objective of this study was to determine the mutagenic and antimutagenic effects of the Aloe vera solution in Allium cepa test and the micronuclei test in human binucleated lymphocytes. For solutions, the leaves of Aloe vera were crushed, filtered and sterilized. The Allium cepa test was composed of eight treatments, and the lymphocytes of five (with four repetitions). It was observed that at the usual dose, the solution of Aloe vera was not mutagenic for the plant test system and not for humans. At a dose ten times more concentrated caused a cytotoxic and mutagenic effect in Allium cepa. In plant cells the solution was antimutagenic only when placed after paracetamol, while in human cells, this action was manifested when the solution was used at the same time with paracetamol.

【 授权许可】

Unknown