Interference from extracts of Baccharis dracunculifolia DC., Asteraceae, on the activity of antibiotics used in the clinic

Revista Brasileira de Farmacognosia

Onofre, Sideney Becker¹  Universidade Paranaense, Francisco Beltrão, Brasil¹  Canton, Marilde¹ 

关键词: medicinal plants;    essential oils;    antibiotics;    associated use;    interference;    Baccharis drancunculifolia.;   

DOI  :  10.1590/S0102-695X2010000300010

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The objective of this study was to investigate the interference of the polar and apolar fraction as well the essential oil of Baccharis dracunculifolia DC., Asteraceae, about the antibiotics effects used in the medic clinic. The essays were accomplished with twenty nine antibiotics in association with two extracts [one polar fraction (HA 50%) and one of apolar fraction (EA 25%)] and with essential oil. The method used was the diffusion one in solid mean using the antibiotic discs, which were acquired commercially. The results showed interference in the hoped action of the antibiotic when associated to the extract and to the B. dracunculifolia essential oil. In some cases there was no alteration of the antibiotic action, however, in most of the cases there was either a synergic or an antagonic interference of the antibiotic action. These outcomes have showed that the use of derived products or plants can interfere on the effectiveness of the antibiotic use in the clinic treatment, in some situations.

【 授权许可】

Unknown