Influence of the preparation method on the low efficacy of multi-herb commercial products: the example of João da Costa e Associações

Revista Brasileira de Farmacognosia

Tagliati, Carlos A.¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brazil¹  Universidade Bandeirante de São Paulo, São Paulo, Brazil¹  Cosenza, Gustavo P.¹  Brandão, Maria G. L.¹  Cesar, Isabela C.¹  Museu de História Natural e Jardim Botânico, Belo Horizonte, Brazil¹  Marques, Luis C.¹ 

关键词: native species;    commercial product;    Himatanthus lancifolius;    Chondodendron platyphyllum;    Gossypium herbaceum;    Echites peltata.;   

DOI  :  10.1590/S0102-695X2010000200019

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Native medicinal plants have been used for decades by Brazilian pharmaceutical companies to create commercial products. In this study, we have investigated the herb-combined product João da Costa e Associações® (JCA) commercialized for thirty years to treat dysmenorrhoea. JCA is prepared by decoction of Himatanthus lancifolius (Muell. Arg.) Woodson (Apocynaceae), Chondodendron platyphyllum Miers (Menispermaceae), Gossypium herbaceum L. (Malvaceae), Rosmarinus officinalis L. (Lamiaceae) and Echites peltata (Apocynaceae), followed by addition of sugar. The efficacy of JCA was verified by antinociceptive studies. The chemical composition was determined by fingerprint analysis in HPLC/ DAD. A weak inhibition of the second phase of the nociceptive effect induced by formalin indicated an activity similar to those steroids and not-steroids anti-inflammatories. Despite being prepared by decoction of five plants, the fingerprint analysis showed only two peaks. None of them corresponds to the chemical compounds observed in ethanol extracts prepared with the same plant material. We argue that the methods of preparation of the formulas should be considered in studies of multi-herbs products, since they can be the responsible for inefficacy or low activity of such products.

【 授权许可】

Unknown