期刊论文详细信息
Revista Brasileira de Farmacognosia | |
Isolation, identification and antileukemic activity of the monoterpene indole alkaloids from Tabernaemontana salzmannii A. DC., Apocynaceae | |
Braz-Filho, Raimundo1  de Souza, Jucimar J.1  Côrtes, Fernanda H.1  Mathias, Leda1  Kanashiro, Milton M.1  Vieira, Ivo J. C.1  Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brasil1  Figueiredo, Elaine R.1  | |
关键词: Tabernaemontana salzmannii; Apocynaceae; indole alkaloids; antileukemic activity.; | |
DOI : 10.1590/S0102-695X2010000100016 | |
来源: Sociedade Brasileira de Farmacognosia | |
【 摘 要 】
This work describes the isolation and structural determination of nine monoterpenic indole alkaloids from the root barks and leaves of Tabernaemontana salzmannii. The alkaloids were identified by spectroscopic methods uni (NMR 1H, 13C, APT) and two-dimensional (1H-1H-COSY, 1H-1H-NOESY, HMQC and HMBC) and mass spectra besides comparison with literature data. An in vitro screening was done with the isolated major alkaloids. Among the nine alkaloids isolated, isovoacangine and voacangine alkaloids were able to induce apoptosis cell death in human leukemic cells line THP-1.
【 授权许可】
Unknown
【 预 览 】
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RO201912010145320ZK.pdf | 957KB | download |