Isolation, identification and antileukemic activity of the monoterpene indole alkaloids from Tabernaemontana salzmannii A. DC., Apocynaceae

Revista Brasileira de Farmacognosia

Braz-Filho, Raimundo¹  de Souza, Jucimar J.¹  Côrtes, Fernanda H.¹  Mathias, Leda¹  Kanashiro, Milton M.¹  Vieira, Ivo J. C.¹  Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brasil¹  Figueiredo, Elaine R.¹ 

关键词: Tabernaemontana salzmannii;    Apocynaceae;    indole alkaloids;    antileukemic activity.;   

DOI  :  10.1590/S0102-695X2010000100016

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

This work describes the isolation and structural determination of nine monoterpenic indole alkaloids from the root barks and leaves of Tabernaemontana salzmannii. The alkaloids were identified by spectroscopic methods uni (NMR 1H, 13C, APT) and two-dimensional (1H-1H-COSY, 1H-1H-NOESY, HMQC and HMBC) and mass spectra besides comparison with literature data. An in vitro screening was done with the isolated major alkaloids. Among the nine alkaloids isolated, isovoacangine and voacangine alkaloids were able to induce apoptosis cell death in human leukemic cells line THP-1.

【 授权许可】

Unknown