Hepatic protection effect of the alcoholic extract from Camellia sinensis (L.) Kuntze (green tea) in Wistar rats treated with diethylnitrosamine

Revista Brasileira de Farmacognosia

Cecchini, Rubens¹  Universidade Estadual de Londrina, Londrina, Brasil¹  Centro Universitário da Grande Dourados, Dourados, Brasil¹  Estevão, Dirceu¹  Saridakis, Halha Ostrensky¹  Schmitz, Wanderlei Onofre¹ 

关键词: Camellia sinensis;    Theaceae;    hepatic protection;    diethylnitrosamine;    catechins.;   

DOI  :  10.1590/S0102-695X2009000500009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Green tea (Camellia sinensis (L.) Kuntze) is used for its properties: antioxidant, chemoprotector and anti-inflammatory in several pathological situations, mainly those facing carcinogen chemical substances. This work has evaluated the hepatic protection effect of the green tea extract (GTE) on lipoperoxidation and necrosis, induced by the carcinogenic DEN in rats´ liver. Adult male Wistar rats were used and exposed to one only intra peritoneal dose of 200 mg/kg of DEN, and orally 120 mg/kg of ECV in different experimental moments. After 24 h of a DEN treatment, the animals were sacrificed and the following aspects were evaluated: the AST/ALT levels in plasma, lipoperoxidation of TBARS and FOX in the liver. Necrosis and Hepatic hemorrhage were observed through a histological examination. The chemoprotector action and the decrease in lipoperoxidation were detected after a decrease of AST/ALT, TBARS, FOX and hepatic necrosis. The evaluation of these results confirmed the importance of the use of the green tea as a chemoprotector agent, particularly as a preventive method.

【 授权许可】

Unknown