Anti-inflammatory activity of the aqueous extract of Arrabidaea chica (Humb. & Bonpl.) B. Verl. on the self-induced inflammatory process from venoms amazonians snakes

Revista Brasileira de Farmacognosia

Universidade Federal do Amazonas, Manaus, Brasil¹  Borrás, Maria Rosa Lozano¹  López-Lozano, Jorge Luis¹  Oliveira, Denys Paixão Costa de¹  Ferreira, Luis Carlos de Lima¹  Fundação de Medicina Tropical do Amazonas, Manaus, Brasil¹ 

关键词: Arrabidaea chica;    Bignoniaceae;    medicinal plants;    venoms;    snakes;    anti-inflammatory activity.;   

DOI  :  10.1590/S0102-695X2009000400024

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The study investigated the anti-inflammatory effects of the aqueous extract (EAq), the Arrabidaea chica (Humb. & Bonpl.) B. Verl., Bignoniaceae, known as the "crajiru", tested on the paw oedema induced in inflammatory process by venoms Amazon snakes from the Bothrops and Crotalus species, on albino mice. This process was done by an oral, intraperitoneal and subcutaneous way. The cushions thickness was measured at time breaks of 1, 3, 6, 12 and 24 hours, Bothrops genus and 1, 3 and 6 hours, Crotalus genus, and a histopathologic analysis was made. The Bothrops genus, was used as an inhibitory effect for the subcutaneous and intraperitoneal way (12 hours), and it had an inhibition of 55.87% and 65.70%, respectively. For the Crotalus genus, the inhibitory effect for the subcutaneous way after 3 hours was the 33.55% and 79.81%, after 6 hours. The intraperitoneal way affect after 3 hours had an inhibition of 48.02% and 92.52% after 6 hours. For the histopathological analysis, the leucocytes infiltration and the miocitolisis were the most expressive parameters and thus inhibited. The results suggest the presence of active principles with anti-inflammatory effects.

【 授权许可】

Unknown