Pharmacological evaluation of a phytotherapeutic product - CPV (dry extract of Crataegus oxyacantha L., Passiflora incarnata L. and Valeriana officinalis L.) in laboratory animals

Revista Brasileira de Farmacognosia

Mattei, Rita¹  Universidade Federal de São Paulo, São Paulo, Brazil¹  Carlini, Elisaldo Luiz de Araujo¹  Tabach, Ricardo¹ 

关键词: Passiflora incarnata;    Crataegus oxyacantha;    Valeriana officinalis;    Passifloraceae;    Rosaceae;    Valerianaceae;    anxiolytic effects;    CNS.;   

DOI  :  10.1590/S0102-695X2009000200013

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The aim of the present study was to evaluate the central effects of the phytotherapeutic product-CPV (dry extract of Crataegus oxyacantha, Passiflora incarnata and Valeriana officinalis) in animals models. In order to investigate the psychopharmacological profile of CPV extract, an evaluation toward anxiolytic effect of this extract on the elevated plus-maze (EPM) was carried out. Other effects such as neuroleptic (blockade of the stereotyped behavior induced by apomorphine), analgesic (hot plate; acetic acid writhing and tail-flick tests) and on the memory (passive avoidance test) were also analyzed. CPV extract (430 and 860 mg/ kg) presented an anxiolytic effect on rats (increased the number of entries into the open arms in the EPM) and, furthermore, a tendency of slight amnesic effect for the doses (430 and 860 mg/kg), but less intense when compared to diazepam (1.5 mg/kg). The extract did not show neuroleptic or analgesic effects.

【 授权许可】

Unknown