Production of plant secondary metabolites in plant cell and tissue culture: the example of Tabernaemontana and Aspidosperma genera

Revista Brasileira de Farmacognosia

Gonçalves, Regina Aparecida Correia¹  Machado, Maria de Fátima Pires Silva¹  Fumagali, Elisângela¹  Universidade Estadual de Maringá, Maringá, Brasil¹  Vidoti, Gentil José¹  Oliveira, Arildo José Braz de¹ 

关键词: Secondary metabolites;    indolic alkaloids;    plant cell culture;    Apocynaceae;    Aspidosperma;    Tabernaemontana.;   

DOI  :  10.1590/S0102-695X2008000400022

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Studies on plant secondary metabolites have been increasing over the last 50 years. These compounds are known to play a major role in the adaptation of plants to their environment and an important source of active pharmaceuticals. Plant cell culture technologies were introduced at the end of the 1960s as a possible tool for both studying and producing plant secondary metabolites. Different strategies, using in vitro systems, have been extensively studied with the objective of improving the production of secondary plant compounds. The Aspidosperma and Tabernaemontana genera are an important source of biologically active alkaloids and in Brazil there is a considerable number of species of these genera. About 16 years ago cell cultures of Tabernemontana and Aspidosperma were initiated. These cell cultures did produce a number of alkaloids of pharmaceutical interest that stimulated the development of several techniques to production, extraction and identification.

【 授权许可】

Unknown