Pharmacological properties of the ethanol extract from Eremanthus erythropappus (DC.) McLeisch (Asteraceae)

Revista Brasileira de Farmacognosia

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Sousa, Orlando V.¹  Kaplan, Maria A. C.¹  Silvério, Marcelo S.¹  Matheus, Filipe C.¹  Miranda, Mariza A.¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹  Del-Vechio-Vieira, Glauciemar¹ 

关键词: Eremanthus erythropappus;    antinociceptive activity;    anti-inflammatory activity;    antiulcerogenic activity.;   

DOI  :  10.1590/S0102-695X2008000300017

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The present work investigated the antinociceptive, anti-inflammatory and antiulcerogenic activities of Eremanthus erythropappus ethanol extract. The tests were carried out by acetic acid writhing, paw licking induced by formalin, hot plate, indomethacin- and ethanol-induced ulcer. The doses of 50, 100 and 200 mg/kg inhibited the contortions in 43.07, 69.34 and 70.07%, respectively. Both phases of paw lick were reduced at the tested doses, while reaction time at hot plate had significant effect at 200 mg/kg. The paw edema was decreased in 23.81% (100 mg/kg) and 47.62% (200 mg/kg). The index of ulceration induced by indomethacin was reduced at the doses of 100 and 200 mg/kg, while 200 mg/kg decreased the gastric volume and pH. The index of ulceration and gastric volume induced by ethanol was reduced at 200 mg/kg, while the pH increased at 100 and 200 mg/kg. The results indicate that the ethanol extract from E. erythropappus may constitute a potential target for the use in therapies of the pain, inflammation and ulcer.

【 授权许可】

Unknown