Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba

Revista Brasileira de Farmacognosia

University of Ulster, Londonderry, UK¹  Majumder, Muntasir M.¹  Akter, Raushanara¹  Alam, M. Ashraful¹  Subhan, Nusrat¹  Nahar, Lutfun¹  Stamford University, Dhaka, Bangladesh¹  Rahman, M. Mostafizur¹  Sarker, Satyajit D.¹ 

关键词: Anthocephalus cadamba;    Rubiaceae;    Antidiarrhoeal;    Castoroil;    Gastrointestinal transit.;   

DOI  :  10.1590/S0102-695X2008000200002

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba was assessed on experimental animals. The dry hydroethanolic extract (250-500 mg/kg body mass, p.o.) exhibited a dose-dependent decrease in the total number of faecal droppings in castor oil-induced diarrhoea in mice. The extract also produced a significant (p < 0.01) and dose-dependent reduction in intestinal fluids accumulation and in the gastrointestinal transit from 64.59 % and 71.19% at doses of 250 and 500 mg/kg. The reduction rates were 37.85% and 74.91%, respectively, with the control and standard drug group.

【 授权许可】

Unknown