Osmotic and morphological effects on red blood cell membrane: action of an aqueous extract of Lantana camara

Revista Brasileira de Farmacognosia

Giani, Tânia S.¹  Instituto Nacional do Câncer, Rio de Janeiro, Brazil¹  Bernardo-Filho, Mario¹  Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil¹  Paoli, Severo de¹  Santos-Filho, Sebastião D.¹  Fonseca, Adenilson S.¹  Universidade Federal do Rio Grande do Norte, Natal, Brazil¹  Presta, Giuseppe A.¹  Maiworm, Adalgisa I.¹ 

关键词: Lantana camara;    Verbenaceae;    morphology;    red blood cells;    osmotic fragility.;   

DOI  :  10.1590/S0102-695X2008000100010

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The Lantana camara ("cambara de espinho") leaves infusions are used popularly in some countries to treat gastrointestinal diseases. Osmotic fragility assay and morphometric analysis have been used to verify the interaction of drugs with the membrane of red blood cells (RBC). The aim of this work was to evaluate the effects of an aqueous extract of Lantana camara on the osmotic fragility and on the morphology of RBC. Blood samples were treated with extract of Lantana camara (10 mg/mL), osmotic fragility assay and morphological analysis were carried out. In the presence of the extract, the data obtained indicated (i) a significant (p < 0.05) increase of hemolysis and (ii) modifications on the morphology of RBC. These effects of the Lantana camara may be associated with some pharmacological properties of the chemical compounds of this studied extract.

【 授权许可】

Unknown