Investigation on miorelaxant, antispasmodic and analgesic effects of the aqueous extract of Phoradendron piperoides

Revista Brasileira de Farmacognosia

Mello, Iderjane C. M.¹  Santos, Thiago C.¹  Marques, Maxsuel S.¹  Menezes, Igor A. C.¹  Antoniolli, Ângelo R.¹  Marçal, Rosilene M.¹  Silva, Aline B. L.¹  Dias, Kellyane S.¹  Universidade Federal de Sergipe, São Cristóvão, Brasil¹  Almeida, Dayse S.¹  Carvalho, Ana C. S.¹ 

关键词: Phoradendron piperoides;    Viscaceae;    miorelaxant;    antispasmodic;    antinociceptive;    acute toxicity.;   

DOI  :  10.1590/S0102-695X2007000300012

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The present work evaluated the antinociceptive, miorelaxant and antispasmodic effects as well as the acute toxicity of the aqueous extract from leaves of Phoradendron piperoides. In guinea pig ileum, the plant extract (0.05 - 2.0 mg/kg) decreased the preparations basal tone in a dose-dependent manner (IC50 = 0.114 mg/mL) and it (1.5 mg/mL) reduced (p < 0.001) the contractions induced by carbachol (2 µM), histamine (2 µM) and BaCl2 (0.03M). The extract, at oral doses of 100, 200, and 400 mg/kg, did not manifest a significant antinociceptive effect in the writhing, formalin and hot-plate tests. Moreover, no animal deaths were observed in doses up to 5 g/kg. In conclusion, the aqueous extract of Phoradendron piperoides showed no antinociceptive effect and no acute toxicity in mice. Indeed, it revealed miorelaxant and antispasmodic activities that are probably miogenic and not specific for neurotransmitters.

【 授权许可】

Unknown