Fractionation of dichlorometane extract from Senecio desiderabilis Vellozo and evaluation of the antimicrobial activity

Revista Brasileira de Farmacognosia

Camargo, Tarcisio de¹  Deuschle, Régis A. N.¹  Universidade Federal de Santa Maria, Santa Maria, Brasil¹  Heizmann, Berta M.¹  Mallmann, Carlos A.¹  Alves, Sydney H.¹ 

关键词: Senecio desiderabilis;    Asteraceae;    antimicrobial activity;    sesquiterpene;    germacrene D.;   

DOI  :  10.1590/S0102-695X2007000200015

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The present work describes the evaluation of the antimicrobial activity of a sesquiterpene fraction obtained from CH2Cl2 extract of Senecio desiderabilis Vellozo (Asteraceae), and of germacrene D isolated from it. The sesquiterpene fraction and the isolated substance were obtained by column chromatography and analysed by GC-MS. Substance identification was carried out by NMR. The antimicrobial activity was assayed by broth microdilution method, as preconized by NCCLS in the documents M27-A for yeasts and M7-A4 for bacteria. The sesquiterpene fraction showed moderated antimicrobial activity, and germacrene D did not inhibit the tested microorganisms.

【 授权许可】

Unknown