Natural products with antileprotic activity

Revista Brasileira de Farmacognosia

Tomaz, Anna Cláudia de Andrade¹  Diniz, Margareth F.F. Melo¹  Athayde-Filho, Petrônio F. de¹  Nascimento Júnior, Francisco A. do¹  Silva, Marcelo S. da¹  Cunha, Emídio V. Leitão da¹  Barbosa-Filho, José M.¹  Batista, Leônia M.¹  Universidade Federal da Paraíba¹  Souza, Maria de F. Vanderlei de¹ 

关键词: Mycobacterium leprae;    lepra;    leprosy;    HansenÂ’s disease;    natural products;    medicinal plants;    revision.;   

DOI  :  10.1590/S0102-695X2007000100022

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus. It was considered to be an incurable disease for ages. Nowadays leprosy is a vanishing disease although we can meet it principally in the tropical zone countries. Brazil has the second greatest number of leprosy cases around the world with almost 30,000 new cases diagnosed in 2005. The present work constitutes a literature review on plant extracts and chemically defined molecules of natural origin showing antileprotic activity. The review refers to 11 plants, their families, and geographical distribution, the utilized parts, the type of extract and the tested organism. It also includes 17 compounds isolated from higher plants and microorganisms, classified into appropriate chemical groups. Some aspects of recent antileprotic-activity-directed research on natural products are discussed. For this purpose 63 references were consulted.

【 授权许可】

Unknown