In vitro antimicrobial activity and determination of the minimum inhibitory concentration (MIC) of natural and synthetic compounds against bacteria and leveduriform fungi

Revista Brasileira de Farmacognosia

Antunes, Rossana M. Pessoa¹  Dias, Celidarque S.¹  Universidade Rural de Pernambuco, Recife, Brasil¹  Pereira, Maria S.V.¹  Nunes, Xirley P.¹  Universidade Estadual da Paraíba, Campina Grande, Brasil¹  Camara, Celso A.¹  Lima, Edeltrudes O.¹  Arruda, Thúlio A.¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹  Barbosa, Ticiano P.¹  Silva, Tânia M. Sarmento¹  Catão, Raissa M. Ramalho¹  Universidade Federal da Bahia, Vitória da Conquista, Brasil¹ 

关键词: Antimicrobial activity;    phytoconstituents;    synthetic substances;    yangambin;    lapachol;    bacteria;    yeast.;   

DOI  :  10.1590/S0102-695X2006000400014

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Regarding the problem of microbial resistance, the researches point to the use of new antibiotic which can be active against the emergent pathogens. This work aims to test the activity against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli e Pseudomonas aeruginosa) and leveduriform fungi (Candida albicans), and also the Minimum Inhibitory Concentration (MIC) of the constituent of Ocotea duckei Vattimo, lapachol and its synthetic derivatives a-lapachone, b-nor-lapachone, b-lapachone, a-nor-lapachone, b-3-iodin-lapachone and a-3-iodin–lapachone, as well as seven nitrogenated derivatives of lapachol obtained through semi synthesis. The achieved results stimulate the deepening of the studies for some of theses substances such as lapachol and its analogous which demonstrated antimicrobial activity. The substances which were active against S. aureus, were lapachol and the ethanolic extract of Ocotea duckei Vattimo, against Escherichia coli iangambin and against C. albicans the imides. The other substances did not show any activity against the tested bacteria.

【 授权许可】

Unknown