Evaluation of the analgesic effect and acute toxicity of the aqueous extract of Hyptis fruticosa (Salmz. ex Benth.)

Revista Brasileira de Farmacognosia

Antoniolli, Angelo R.¹  Mello, Iderjane C.M.¹  Menezes, Igor A.C.¹  Santos, Thiago C.¹  Silva, Aline B.L.¹  Marques, Maxsuel S.¹  Marçal, Rosilene M.¹  Lisboa, Ana Carla C.D.¹  Dias, Kellyane S.¹  Universidade Federal de Sergipe, São Cristóvão, Brasil¹  Cavalcanti, Sócrates C.H.¹ 

关键词: Hyptis fruticosa;    Lamiaceae;    antinociceptive;    aqueous extract;    acute toxicity.;   

DOI  :  10.1590/S0102-695X2006000400006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The antinociceptive effect and the acute toxicity of Hyptis fruticosa leaves were evaluated through the administration of its aqueous extract in mice. The extract, administered orally (200, 400, and 500 mg/kg), reduced the nociceptive response in the writhing test as well as in the early phase of the formalin test (100 and 400 mg/kg) and it increased the latency time in the hot plate test (100 and 200 mg/kg). The antinociceptive effect was reversed by naloxone (5 mg/kg, i.p.). Moreover, no animal deaths were observed in doses up to 5 g/kg. In conclusion, the aqueous extract of Hyptis fruticosa showed no acute toxicity at the evaluated doses and revealed antinociceptive effect in mice. Such effects are possibly associated with the opioid system activation.

【 授权许可】

Unknown