Phytochemical studies of the extracts of stem bark and leaves of Eugenia malaccensis L. (Myrtaceae) and evaluation of their molluscicidal and larvicidal activities

Revista Brasileira de Farmacognosia

Sant'Ana, Antônio Euzébio Goulart¹  Silva, José Marcos da¹  Universidade Federal de Alagoas, Maceió, Brasil¹  Humberto, Margarida Maria dos Santos¹  Oliveira, Anderson Marques de¹  Rocha, Rosário de Fátima de Almeida¹ 

关键词: Biomphalaria glabrata;    Eugenia malaccensis;    Myrtaceae;    flavonols;    3-acetyl-urs-12-en-28-oic acid.;   

DOI  :  10.1590/S0102-695X2006000500006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Eugenia malaccensis L. (Syzygium malaccensis Merr. & Perry), popularly known in Brazil as jambo vermelho, is a very common tree and one of the medicinal plants of Alagoas State, Brazil. Previous chemical studies with E. malaccensis have been carried out with native plants from Asia, Oceania, and Central America. This work describes the chemical study of E. malaccensis L., a specimen collected in Alagoas State. Considering that studies on the molluscicidal and larvicidal potential of E. malaccensis were not reported, this work aimed to test its molluscicidal activity against Biomphalaria glabrata snails and larvicidal activity against Aedes aegypti mosquitos. The ethanolic stem bark and leaf extracts were inactive towards Aedes aegypti larvae. The ethanolic stem bark and leaf extract were active against Biomphalaria glabrata with CL50 = 42.53 and 41.90 mg/mL, respectively. 5,7,3',4',5'-Penta-hydroxy-flavonol (1), 5,7,3',5'-tetra-hydroxy-4'-methoxy-flavonol (2), 3,4,5-tri-hydroxybenzoic acid (3) and 3-acetyl-urs-12-en-28-oic acid (4) were isolated and identified from the leaves and stem bark. The acid 3b-O-acetyl-urs-12-en-28-oic is for the first time isolated from the genus Eugenia. The structures of the compounds have been established by IR, 1H and 13C NMR spectral analysis and by comparison with literature data.

【 授权许可】

Unknown