Avaliação toxicológica aguda e screening hipocrático da epiisopilosina, alcalóide secundário de Pilocarpus microphyllus Stapf.

Revista Brasileira de Farmacognosia

Rosalen, P.L.¹  Universidade Federal Fluminense¹  Sharapin, N.¹  Souza Brito, A.R.M.¹  Lucio, E. M. R. de A.¹  Universidade Estadual de Campinas¹ 

关键词: epiisopilosine;    toxicologic evaluation;    hipocratic screening;    acute toxicity;    jaborandi;    pilocarpine.;   

DOI  :  10.1590/S0102-695X2000000100003

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Pilocarpus microphyllus Stapf. (Rutaceae) is a source for industrial isolation of pilocarpine, alkaloid used in the treatment of glaucoma. It contains several secondary alkaloids; one of them being eplisopilosine. Pharmacological evaluation showed DL50 value of epiisopilosine two times higher than of pilocarpine. Epiisopilosine also showed to be a pilocarpine-like peripheric stimulant of parasympatic nervous system, although in higher dosis.

【 授权许可】

Unknown