Amifostine: An Effective Prophylactic Agent against Sulphur Mustard Toxicity (Short Communication)

Defence Science Journal

S. K. Raza¹  Uma Pathak¹  R. Vijayaraghavan¹  D. K. Jaiswal¹  P. Kumar¹ 

[1] Defence Research & Development Establishment, Gwalior

关键词: Amifostine;    sulphur mustard;    prophylactic agent;    radioprotector;    toxicity;    alkylating agent;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Defence Scientific Information & Documentation Centre

【 摘 要 】

Amifostine, S-2-(aminopropylamino)ethylphosphorothioate and two of its analogues have been evaluated asprophylactic agent against SM toxicity. The compounds were administeredintraperitoncally (i.p.) at 0.2 LD/sub59 dose in mice 30 min prior todermal application of SM. The protective efficacy was determined byobserving the mortality for 14 days. The protection offered byamifostine was better than its analogues. Subsequent study ontime-dependent protection, carried out with amifostine (0.2 LD/sub50,i.p.) provided significant protection when the drug was administered as30 min pre-treatment and simultaneous treatment against SM at 155mg.kg/-1 dose (equal to 19-fold LD/sub50). Furthermore, oraladministration of amifostine (30 min pre-treatment) showed similarresults. These findings suggest that amifostine is a promisingprophylactic agent against SM toxicity.

【 授权许可】

Unknown