Changes in Plasma Leptin and Zinc Status of Women Mountaineers at High Altitude (Short Communication)

Defence Science Journal

Som Nath Singh¹  Shoba Suri¹  W. Selvamurthy¹  Ashok Salhan¹ 

[1] Defence Institute of Physiology & Allied Sciences, Delhi

关键词: Leptin;    zinc;    high altitude;    women mountaineers;    alkaline phosphatase;    5';    nucleotidase;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Defence Scientific Information & Documentation Centre

【 摘 要 】

The loss of body weight due to suppressedappetite at high altitude is very common. The hormone leptin and tracemetal zinc have key roles in appetite regulation. In the present study,changes in leptin and zinc status of female mountaineers with andwithout supplementation with zinc have been investigated. Plasma leptin,zinc and enzyme activities of alkaline phosphatase (EC 3.1.3.5) and 5'nucleotidase (EC 3.1.3.1) of 25 women mountaineers between age group17-25 yr were studied. The women mountaineers were divided into twogroups, i.e., placebo control (n = 7) and supplemented with zinc at dose15 mg/day for 21 days (n = 18) and all variables were analysedinitially at 1981 m, at high altitude (4572-5182 m) and on return toinitial altitude. The basal leptin level for both the groups combinedwas 3.12 ± 0.57 ng/ml (mean ± SD). Plasma leptin levels were foundincreased by 24 per cent and 58 per cent, respectively at high altitudeand after return in case of control group, whereas in case ofzinc-supplemented group, there was a statistically non-significantdecrease of 20 per cent at high altitude in comparison to basal values.Thereafter, levels were maintained at baseline. There was no significantchange in zinc status of control group as indicated by plasma zinc aswell as maintained activities of alkaline phosphatase and 5'nucleotidase in the present study. On the other hand, zinc-supplementedgroup showed increase in zinc status at high altitude, which was evidentby increased plasma zinc levels. On return from high altitude, plasmazinc levels were low in comparison to high altitude but still higherthan that of basal. Results indicate beneficial effects of zincsupplementation by decreasing leptin levels at high altitude

【 授权许可】

Unknown