Prevention of AIDS and sexually transmitted infections (Review Paper)

Defence Science Journal

G.P. Talwar¹ 

[1] Talwar Research Foundation, Neb Serai, New Delhi

关键词: AIDS;    Sexually transmitted infections;    Polyherbal formulations;    Reproductive tract infections;    Spermicides;    Microbicides;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Defence Scientific Information & Documentation Centre

【 摘 要 】

Abnormal vaginal discharge due toreproductive tract infections (RTIs) is widely prevalent in the country.According to WHO, over 300 million new cases of sexually-transmittedinfections (excluding HIV) occur each year. In addition to these, HIVinfection is spreading rapidly in the country with over 3.7 millionsero-positive cases (from zero) within 15 years.. The predominant modeof transmission of HIV is by heterosexual route. The multidrug regimefor treatment is expensive (about $10,000 per year) which is beyond thereach of most of the people. No viable vaccine preventing AIDS infectionis in sight. Under these circumstances, safe sex is the best recourse,which demands consistent and proper use of condoms. This does not takeplace to the extent necessary for preventing the transmission of HIV andother sexually-transmitted infections. A polyherbal tablet forintravaginal use by women has been developed and a polyherbal cream, foruse by both men and women, which has a wide spectrum antimicrobialaction. Amongst others, these inhibit the growth of Neisseria gonorrhea(including strains resistant to penicillin). normal andmultidrug-resistant isolates of urinary tract E. coli, Candida albicans.Candida krusei and Candida tropicalis. Applied intravaginally, theseprevent the transmission of Herpes simplex 2 and Chlamydia Irachomatisin progestin-sensitised mice. Studies conducted at the Institut Pasteur.Paris and Conrad Norfolk, USA, have demonstrated high virucidal actionof these formulations against HIV . Both formulations have undergonephase I clinical trials in five major centres in India and abroad, whichhave indicated the complete safety of these products without any localor systemic side effects. The Drug Controller of India and theInstitutional Ethics Committees have approved phase II clinical trials.The first of these trials was conducted in 88 women with abnormalvaginal discharge due to genital pathogens at the Postgraduate Instituteof Medical Education and Research. Chandigarh. Every woman. who usedthe praneem polyherbals, once every night for seven days, experiencedrelief clinically. irrespective of the nature of the causative pathogen.

【 授权许可】

Unknown