Exposure of Candida to p-anisaldehyde inhibits its growth and ergosterol biosynthesis

The Journal of General and Applied Microbiology

Luqman Ahmad Khan²  Rimple Bhatia²  Sheikh Shreaz²  Sumathi Muralidhar¹  Neelofar Khan²  Nikhat Manzoor²  Seemi F. Basir² 

[1] Regional Sexually Transmitted Disease Centre, Safdarjung Hospital;Department of Biosciences, Jamia Millia Islamia

关键词: antifungal activity;    Candida;    ergosterol;    p-anisaldehyde;   

DOI  :  10.2323/jgam.57.129

学科分类：微生物学和免疫学

来源: Applied Microbiology, Molecular and Cellulrar Biosciences Research Foundation

【 摘 要 】

p-Anisaldehyde (4-methoxybenzaldehyde), an extract from Pimpinella anisum seeds, is a very common digestive herb of north India. Antifungal activity of p-anisaldehyde was investigated on 10 fluconazole-resistant and 5 fluconazole-sensitive Candida strains. Minimum inhibitory concentrations (MIC90) ranged from 250 μg/ml to 600 μg/ml for both sensitive and resistant strains. Ergosterol content was drastically reduced by p-anisaldehyde—62% in sensitive and 66% in resistant strains—but did not corelate well with MIC90 values. It appears that p-anisaldehyde exerts its antifungal effect by decreasing NADPH routed through up-regulation of putative aryl-alcohol dehydrogenases. Cellular toxicity of p-anisaldehyde against H9c2 rat cardiac myoblasts was less than 20% at the highest MIC value. These findings encourage further development of p-anisaldehyde.

【 授权许可】

Unknown