Co-operative Effect Between γ-Aminobutyric Acid A Receptors and Central-Type Benzodiazepine Receptors on Amylase Release in Rat Parotid Acinar Cells

Journal of Pharmacological Sciences

Mitsuru Kawaguchi¹  Migiwa Okubo¹ 

[1] Department of Pharmacology, Tokyo Dental College, Japan

关键词: γ-aminobutyric acid A receptor;    parotid gland;    amylase release;   

DOI  :  10.1254/jphs.09269SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(4)We investigated the inhibitory role of γ-aminobutyric acid A (GABAA) receptors on amylase release and the evidence for functional coupling with central-type benzodiazepine receptors in rat parotid acinar cells. Muscimol and GABA decreased isoprenaline-induced amylase release. This effect was blocked by bicuculline, a GABAA-receptor antagonist, and enhanced by clonazepam, a central-type benzodiazepine-receptor agonist, and diazepam, a central- and peripheral-type benzodiazepine-receptor agonist. Although bicuculline completely blocked the combination effect of GABAA-receptor agonist and clonazepam, it did not completely block the combination effect with diazepam. These results suggest that protein secretion is suppressively regulated by GABAA receptors coupled with central-type benzodiazepine receptors.

【 授权许可】

Unknown