Dietary exposures and oral precancerous lesions in Srikakulam District, Andhra Pradesh, India

Public Health Nutrition

James R Hebert¹  Hemali Mehta¹  Prakash C Gupta¹  Maureen Sanderson¹  Ramesh B Bhonsle¹  Wei Zheng¹  Jane Teas¹ 

关键词: India;    Oral neoplasms;    Precancerous conditions;    Dietary nutrients;   

DOI  :  10.1079/PHN2002249

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Objective:To test the effect of dietary nutrients on oral precancerous lesions in a reverse-smoking (i.e. smoking with the glowing end inside the mouth) population in South India.Design:Case–control. Cases with precancerous lesions were matched to an equal number of lesion-free controls matched on age (±5 years), sex and village. All subjects used tobacco in some form. Dietary data were obtained using an interviewer-administered food-frequency questionnaire, designed for use in this population. All interviews were conducted blinded to the disease status of the subject. Data were analysed using logistic regression.Setting:Nineteen rural villages in Srikakulam District, Andhra Pradesh.Subjects:From a survey of 6007 tobacco users, 485 (79% women) were found to have precancerous, mostly palatal, lesions (cases), and 487 lesion-free subjects were selected as controls.Results:All eligible subjects consented to participate and nearly all (>99%) had complete data for analyses. Reverse smoking was the most common form of tobacco use among cases (81.9%) and controls (73.5%), and reverse smokers were 5.19 times more likely than chewers to have these lesions (95% confidence interval = 1.35, 19.9). After controlling for relevant covariates, including the type of tobacco use, protective linear effects were observed for zinc (70% reduction across the interquartile range, P

【 授权许可】

Unknown