Active Expression of Matrix Metalloproteinase-13 mRNA in the Granulation Tissue of Equine Superficial Digital Flexor Tendinitis

Journal of Veterinary Medical Science

Atsutoshi KUWANO²  Yoshinori KASASHIMA²  Yoshinao HOSAKA³  Kazushige TAKEHANA³  Masayuki NOMURA³  Katsuhiko ARAI¹  Hiromi UEDA³ 

[1] Department of Tissue Physiology, Tokyo University of Agriculture and Technology;Laboratory of Clinical Science and Pathobiology, Equine Research Institute, Japan Racing Association;Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University

关键词: equine;    MMP-13;    tendinitis;   

DOI  :  10.1292/jvms.69.637

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(15)The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon. In situ hybridization also revealed that fibroblastic cells proliferated in the granulation tissue generated in the tendinitis actively expressed MMP-13 mRNA. On the other hand, in normal tendon, a few fibroblastic cells and vascular components lied in the endotenon barely expressed its mRNA, but other cellular components in the tendon bundle were not positively hybridized. As mentioned above, MMP-13 but not other collagenases or gelatinases, may play an important role in tendon injuries in the racehorses.

【 授权许可】

Unknown