Ability of Orally Administered IFN-α4 to Inhibit Naturally Occurring Gingival Inflammation in Dogs

Journal of Veterinary Medical Science

Ko SATO¹  Emiko ISOGAI²  Toru GOTANDA¹  Akira ITO³  Naomi HIMENO¹  Kuniaki YOSHIOKA¹ 

[1] Research Center for Biologicals, The Kitasato Institute;Department of Preventive Dentistry, Health Sciences University of Hokkaido;Research Institute of Genome-Based Biofactory, National Institute of Advanced Industrial and Science Technology (AIST)

关键词: canine;    cytokine;    interferon;    periodontics;    therapy;   

DOI  :  10.1292/jvms.09-0201

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(41)Cited-By(4)It has been reported that type I interferons (IFN-α/β) play an important role in innate immune responses against viral and bacterial infections. In this study, we used and examined naturally occurred canine periodontal disease to show the therapeutic efficacy of low dose oral administration (LDOA) of canine IFN-α subtype 4 (CaIFN-α4). We administered purified recombinant CaIFN-α4 expressed in a baculovirus system to dogs with or without gingival inflammation. We found that LDOA of CaIFN-α4 reduce periodontopathic bactrerial counts. LDOA induced improvement of naturally occurring gingival inflammation, and reduction of the stress marker responses was also observed after LDOA. These results suggest that LDOA of CaIFN-α4 has effectiveness for improvement of naturally occurring gingival inflammation in dogs.

【 授权许可】

Unknown