Cell therapy for the treatment of lower limb lymphedema. Case report

Revista Cubana de Hematología, Inmunología y Hemoterapia

Perera-Pintado, Alejandro¹  Hernández-Ramírez, Porfirio²  Marsán-Suárez, Vianed²  Peña-Quían, Yamilé¹  Artaza-Sanz, Heriberto³  Goicoechea-Díaz, Pedro³  Cortina-Rosales, Lázaro² 

[1] Centro de Investigaciones Clínicas, Ciudad de La Habana, Cuba;Instituto de Hematología e Inmunología, Ciudad de La Habana, Cuba;Hospital General Docente Enrique Cabrera, Ciudad de La Habana, Cuba

关键词: : Stem cell;    lymphedema;    bone-marrow derived cells;    lymphangiogenesis;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

Although lymphedema is a common disabling disease causing significant morbidity for affected patients, treatment for this condition remains limited and largely ineffective. Some reported data suggest that some bone-marrow derived cells may play a role in lymphangiogenesis. It appears that blood vessels and lymphatic vessels might use the same population of cells for vasculogenesis and lymphangiogenesis. Therefore, adult stem cell therapy could be a new useful strategy for the treatment of lymphedema. We report a resolution of a severe lower limb bilateral lymphedema after implantation of autologous adult stem cells derived from bone marrow. As far as we know, this is the first reported case with chronic lower limb lymphedema treated successfully with autologous cell therapy. This procedure is a low-cost, relatively simple and easy to perform option that opens new ways for the treatment of lymphedema.

【 授权许可】

CC BY-NC