Radionuclide Therapy of Bone Metastases

Breast care

Willm U. Kampen¹  Manfred Fischer¹ 

[1] aPraxis für Radiologie und Nuklearmedizin, Kassel, Germany

关键词: Bone metastases;    Pain palliation;    Radionuclides;    ¹⁵³Sm-EDTMP;    ⁸⁹Sr;    ²²³Ra;   

DOI  :  10.1159/000337634

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

The skeleton is a potential metastatic target of many malignant tumors. Up to 85% of prostate and breast cancer patients may develop bone metastases causing severe pain syndromes in many of them. In patients suffering from multilocular, mainly osteoblastic lesions and pain syndrome, radionuclide therapy is recommended for pain palliation. Low-energy beta-emitting radionuclides (153samarium-ethylenediaminetetrameth-ylenephosphonate (EDTMP) and 89strontium) deliver high radiation doses to bone metastases and micrometastases in the bone marrow, but only negligible doses to the hematopoietic marrow. The response rate regarding pain syndrome is about 75%; about 25% of the patients may even become pain free. The therapy is repeatable, depending on cell counts. Concomitant treatment with modern bisphosphonates does not interfere with the treatment effects. Clinical trials using a new, not yet approved nuclide (223Radium) and/or combinations of chemotherapy and radionuclides are aiming at a more curative approach.

【 授权许可】

Unknown