Induction of regulatory T cells by statins: alternative therapy for the control of extrinsic asthma

Revista Cubana de Hematología, Inmunología y Hemoterapia

Blanquiceth M, Yurany¹  Velilla H, Paula Andrea¹  Montoya G, Carlos Julio¹  Rodríguez P, Ana Lucía¹ 

[1] Grupo Inmunovirología, Medellín, Colombia

关键词: extrinsic asthma;    regulatory T cells;    FOXP3;    statins;    immunomodulation;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

Extrinsic asthma is caused by an immunological type I hypersensitivity reaction triggered mainly by environmental allergens. Usually, immune response mediated mainly by CD4 + T cells with Th2 profile determines the main features of extrinsic asthma, including infiltration of eosinophils and basophils that mediate chronic inflammation of the airways. It has been observed that regulatory T cells may act as endogenous modulators during asthmatic processes, controlling crisis exacerbation and decreasing tissue damage. Although glucocorticoids are the main treatment for asthma, these only relieve symptoms temporarily and are associated with adverse effects and development of resistance, which has encouraged the development of alternative therapies that modulate the immune response and control chronic inflammation. Recently, it has been postulated that statins may be a promising alternative to reduce the inflammatory response and decrease the morbidity associated with this disease, due to its great immunomodulator potential, especially in the induction of regulatory T cells.

【 授权许可】

CC BY-NC