Outbreak of Cholera Caused by Vibrio cholerae O1 El Tor Variant Strain in Bihar, India

Japanese Journal of Infectious Diseases

Nivedita Ray⁵  T. Ramamurthy⁵  Goutam Chowdhury⁵  Asish K. Mukhopadhyay⁵  Hemanta Koley⁵  Soma Mitra⁵  Rakesh Katyal³  Pradeep Das⁴  Samiran Panda¹  Subrata Ghosh¹  B. L. Sarkar²  Soumik Barman⁵ 

[1] Division of Epidemiology, National Institute of Cholera and Enteric Diseases;Division of Phage, National Institute of Cholera and Enteric Diseases;National Center for Disease Control, Division of Malariology & Coordination;Rajendra Memorial Research Institute of Medical Science (ICMR);Division of Bacteriology, National Institute of Cholera and Enteric Diseases

关键词: cholera outbreak;    disaster;    V. cholerae;    El Tor variant strain;   

DOI  :  10.7883/yoken.67.221

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(34)Cited-By(1)An outbreak of cholera struck Bihar, an Indian state, in August 2008 following a massive flood. Here we report the phenotypic and genotypic characteristics of Vibrio cholerae strains isolated from patients with diarrhea. Rectal swabs were obtained from patients with diarrhea who were admitted to medical camps or the hospital, and the strains were biochemically and serologically characterized. V. cholerae was isolated from 21 (65.6%) of 32 rectal swabs. Serological studies revealed that all the 21 isolates belonged to V. cholerae O1 Ogawa. Mismatch amplification mutation assay (MAMA)-PCR showed that the isolates belonged to El Tor variant group, and pulsed-field gel electrophoresis (PFGE) proved that these isolates were of a different lineage than the conventional El Tor variant strains. These isolates were resistant to several drugs, including ampicillin, streptomycin, tetracycline, nalidixic acid, and furazolidone. The uniqueness of the current report arises from the fact that records of cholera in Bihar are availiable for the early 1960s but not for the next 4 decades. Moreover, the present study is the first to report a cholera outbreak in Bihar that was caused by an El Tor variant strain.

【 授权许可】

Unknown