An Angiotensin Converting Enzyme Inhibitor, Benazepril Can Be Transformed to an Active Metabolite, Benazeprilat, by the Liver of Dogs with Ascitic Pulmonary Heartworm Disease

Journal of Veterinary Medical Science

Yasuhito KUWAHARA¹  Hitoshi KITAGAWA¹  Rieko OHNE¹  Katsuya KITOH¹  Masahiro KONDO²  Yasunori OHBA¹  Masakazu NAKANO²  Yoshihide SASAKI¹ 

[1] Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University;Novartis Animal Health

关键词: ascites;    benazepril;    benazeprilat;    canine;    heartworm disease;   

DOI  :  10.1292/jvms.65.701

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(1)To examine whether an angiotensin converting enzyme (ACE) inhibitor, benazepril, can be transformed to the active metabolite, benazeprilat, by severely injured liver of dogs with ascitic heartworm disease, benazepril hydrochloride was administered orally to dogs once daily for 7 consecutive days at a dose rate of 0.29 mg/kg to 0.63 mg/kg of body weight, and plasma benazepril and benazeprilat concentrations were determined on the 1st and 7th administration days. In 7 dogs with ascitic pulmonary heartworm disease, plasma benazeprilat concentrations tended to be higher than in 7 control dogs both on the 1st and 7th administration days. The peak concentration and area under the concentration-time curve tended to be greater in dogs of the ascites group than in control dogs, but the statistics could not detect significant differences in the time to peak concentration and t1/2 between the control and ascites groups. Plasma ACE activities decreased after administration of benazepril. In dogs with ascitic heartworm disease, benazepril was readily transformed to benazeprilat by the liver, and was effective for suppression of plasma ACE activity.

【 授权许可】

Unknown