Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

Journal of Pharmacological Sciences

Athina Savva²  Konstantinos Leventogiannis²  Theodora Kanni²  Evangelos J. Giamarellos-Bourboulis²  Maria Raftogiannis²  Anastasia Antonopoulou²  Kalliopi Sereti¹  Panagiota Maravitsa²  Androniki Marioli¹  Marianna Georgitsi²  Petros Christopoulos³  Fotini Baziaka²  Maria Mouktaroudi²  Ilianna Pantelidou²  Ioannis M. Koutelidakis³  Korina Lymberopoulou¹  Panagiotis Tsiaoussis³  Thomas Tsaganos²  Vassilios Papaziogas³  Aikaterini Spyridaki² 

[1] Second Department of Internal Medicine, “Sismanogleion�? Athens Hospital, Greece;Fourth Department of Internal Medicine, University of Athens, Medical School, Greece;Second Department of Surgery, University of Thessaloniki, Medical School, Greece

关键词: intravenous paracetamol;    fever;    pain;    analgesia;   

DOI  :  10.1254/jphs.13133FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)One prospective, open-label, non-randomized study was conducted in 100 patients to define the antipyretic and analgesic effect of a new intravenous formulation of 1 g of paracetamol; 71 received paracetamol for the management of fever and 29 received paracetamol for pain relief after abdominal surgery or for neoplastic pain. Serial follow-up measurements of core temperature and of pain intensity were done for 6 h. Additional rescue medications were recorded for 5 days. Blood was sampled for the measurement of free paracetamol (APAP) and of glucuronide-APAP and N-sulfate-APAP by an HPLC assay. Defervescence, defined as core temperature below or equal to 37.1°C, was achieved in 52 patients (73.2%) within a median time of 3 h. Patients failing to become afebrile with the first dose of paracetamol became afebrile when administered other agents as rescue medications. Analgesia was achieved in 25 patients (86.4%) within a median time of 2 h. Serum levels of glucuronide-APAP were greater among non-responders to paracetamol. The presented results suggest that the intravenous formulation of paracetamol is clinically effective depending on drug metabolism.

【 授权许可】

Unknown