The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Journal of Pharmacological Sciences

Giuseppe Molinaro²  Nancy J. Brown¹  Marie Eve Moreau²  Nancy Garbacki⁴  François Marceau³  Albert Adam² 

[1] Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Vanderbilt University;Faculty of Pharmacy, University of Montreal;Centre de Recherche en Rhumatologie et Immunologie, CHUL-CHUQ;Laboratory of Human Physiology, University of Liège

关键词: kallikrein-kinin system;    B1 and B2 receptors;    metallopeptidase;    pharmacological agent;   

DOI  :  10.1254/jphs.SRJ05001X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(310)Cited-By(181)The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metallopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties.

【 授权许可】

Unknown